Hydroxyapatite-based materials of marine origin: A bioactivity and sintering study

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Piccirillo, C (Author) Other; Pullar, RC (Author) Other; Costa, E (Author) Other; Santos Silva, A (Author) FFUP; Pintado, MME (Author) Other; Castro, PML (Author) Other

Journal

Title: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

Vol. 51

Pages: 309-315

ISSN: 0928-4931

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 52 Citations

Scopus - 62 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-00A-98Y

DOI: 10.1016/j.msec.2015.03.020

Abstract (EN): Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/beta-tricalcium phosphate (HAp/beta-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7