Modulation of mammalian apoptotic pathways by intracellular protozoan parasites

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Rodrigues, V (Author) Other; Cordeiro da Silva, A (Author) FFUP; Laforge, M (Author) Other; Ouaissi, A (Author) Other; Silvestre, R (Author) Other; Estaquier, J (Author) Other

Journal

Title: Cellular Microbiology

Vol. 14

Pages: 325-333

ISSN: 1462-5814

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 18 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-CS2

DOI: 10.1111/j.1462-5822.2011.01737.x

Abstract (EN): During intracellular parasitic infections, pathogens and host cells take part in a complex web of events that are crucial for the outcome of the infection. Modulation of host cell apoptosis by pathogens attracted the attention of scientists during the last decade. Apoptosis is an efficient mechanism used by the host to control infection and limit pathogen multiplication and dissemination. In order to ensure completion of their complex life cycles and to guarantee transmission between different hosts, intracellular parasites have developed mechanisms to block apoptosis and sustain the viability of their host cells. Here, we review how some of the most prominent intracellular protozoan parasites modulate the main mammalian apoptotic pathways by emphasizing the advances from the last decade, which have begun to dissect this dynamic and complex interaction.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9