Anti-leishmanial activity of the bisnaphthalimidopropyl derivatives

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Joana Tavares (Author) Other; Ali Ouaissi (Author) Other; Ana Marta Silva (Author) Other; Paul Kong Thoo Lin (Author) Other; Nilanjan Roy (Author) Other; Anabela Cordeiro da Silva (Author) FFUP

Journal

Title: Parasitology International

Vol. 61

Pages: 360-363

ISSN: 1383-5769

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 15 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-002-9X2

DOI: 10.1016/j.parint.2011.11.005

Abstract (EN): Bisnaphthalimidopropyl (BNIP) derivatives were recently identified as inhibitors of the Leishmania Silent Information Regulator 2 (SIR2) NAD(+)-dependent deacetylase. In this report we have for the first time, determined the potential of these compounds to treat visceral leishmaniasis using BALB/c mice chronically infected with Leishmania infantum as a model. These experiments led to the identification of BNIPdiaminooctane (BNIPDaoct) as an effective compound able to induce significant reduction of the parasite load in the spleen and in the liver. Indeed, at a dose of 1 mg/kg, BNIPDaoct was more effective to treat leishmaniasis in a short course treatment (3 or 6 drug administrations) than the standard amphotericin B. Moreover, no indications of hematological toxicity were detected as evaluated by the hemoglobin, hematocrit, white and red blood cell counts, hence making BNIPDaoct a potential therapeutic agent against leishmaniasis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4