Host cell phenotypic variability induced by trypanosomatid-parasite-released immunomodulatory factors: Physiopathological implications

• Type: Another Publication in an International Scientific Journal
• Date: 2004

Authors

Ouaissi, A (Author) Other; Ouaissi, M (Author) Other; Tavares, J (Author) FFUP; Cordeiro Da Silva, A (Author) FFUP

Journal

Title: Journal of Biomedicine and Biotechnology

Vol. 2004

Pages: 167-174

ISSN: 1110-7243

Publisher: HINDAWI PUBLISHING CORPORATION

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-000-9CW

DOI: 10.1155/s1110724304311034

Abstract (EN): The parasitic protozoa Trypanosoma cruzi and Leishmania sp release a variety of molecules into their mammalian hosts (ESA: excretory-secretory products). The effects of these ESA on the host cell function may participate in the establishment of a successful infection, in which the parasite persists for a sufficient period of time to complete its life cycle. A number of regulatory components or processes originating from the parasite that control or regulate the metabolism and the growth of host cell have been identified. The purpose of the present review is to analyze some of the current data related to the parasite ESA that interfere with the host cell physiology. Special attention is given to members of conserved protein families demonstrating remarkable diversity and plasticity of function (ie, glutathione S-transferases and related molecules; members of the trans-sialidase and mucin family; and members of the ribosomal protein family). The identification of parasite target molecules and the elucidation of their mode of action toward the host cell represents a step forward in efforts aimed at an immunotherapeutic or pharmacological control of parasitic infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8