Contribution of Yeast Models to Neurodegeneration Research

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Clara Pereira (Author) Other; Claudia Bessa (Author) Other; Joana Soares (Author) Other; Mariana Leao (Author) Other; Lucilia Saraiva (Author) FFUP

Journal

Title: Journal of Biomedicine and Biotechnology

Vol. 2012

Pages: 1-12

ISSN: 1110-7243

Publisher: HINDAWI PUBLISHING CORPORATION

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 28 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-002-FKG

DOI: 10.1155/2012/941232

Abstract (EN): As a model organism Saccharomyces cerevisiae has greatly contributed to our understanding of many fundamental aspects of cellular biology in higher eukaryotes. More recently, engineered yeast models developed to study endogenous or heterologous proteins that lay at the root of a given disease have become powerful tools for unraveling the molecular basis of complex human diseases like neurodegeneration. Additionally, with the possibility of performing target-directed large-scale screenings, yeast models have emerged as promising first-line approaches in the discovery process of novel therapeutic opportunities against these pathologies. In this paper, several yeast models that have contributed to the uncovering of the etiology and pathogenesis of several neurodegenerative diseases are described, including the most common forms of neurodegeneration worldwide, Alzheimer's, Parkinson's, and Huntington's diseases. Moreover, the potential input of these cell systems in the development of more effective therapies in neurodegeneration, through the identification of genetic and chemical suppressors, is also addressed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12