Endocytosis inhibition during H2O2-induced apoptosis in yeast

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Clara Pereira (Author) Other; Claudia Bessa (Author) Other; Lucilia Saraiva (Author) FFUP

Journal

Title: FEMS Yeast Research

Vol. 12

Pages: 755-760

ISSN: 1567-1356

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 6 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-45H

DOI: 10.1111/j.1567-1364.2012.00825.x

Abstract (EN): Yeast revealed to be a versatile organism for studying endocytosis. Here, inhibition of endocytosis by H2O2 and its correlation with apoptotic cell death were ascertained in Saccharomyces cerevisiae. We found that H2O2 causes alterations in vacuolar morphology and a concentration-dependent inhibition of endocytosis. We also found that H2O2-induced endocytosis inhibition is a reversible process that occurs in the early phase of the apoptotic cascade, preceding chromatin condensation and DNA fragmentation. Additionally, mutants affecting early steps of the endocytic pathway display sensitivity to H2O2. As endocytosis inhibition was also observed with acetic acid, it may be a broader cellular dysfunction of oxidative stress-induced toxicity in yeast.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6