Enthalpies of solution, limiting solubilities, and partial molar heat capacities of n-alcohols in water and in trehalose crowded media

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Bai, G (Author) Other; Nunes, SCC (Author) Other; Rocha, MAA (Author) Other; Santos, LMNBF (Author) FCUP; Ermelinda, M (Author) Other; Eusebio, S (Author) Other; Joao Moreno, M (Author) Other; Bastos, M (Author) FCUP

Journal

Title: Pure and Applied Chemistry

Vol. 86

Pages: 223-231

ISSN: 0033-4545

Publisher: Walter De Gruyter

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-009-7KQ

DOI: 10.1515/pac-2014-5014

Abstract (EN): The enthalpies of solution of alcohols were determined by calorimetry in HEPES and (HEPES + trehalose) at 298.15 K. The used methodology and experiment's design allowed us to extract from a single titration experiment the enthalpy of solution (Delta H-sol(m)), the limiting solubility of the alcohol in each aqueous media, and an estimation of the enthalpy of solution of water in the alcohol phase. From these values the changes in Gibbs energy (Delta(sol)G(m)) and in entropy (Delta S-sol(m)) of solution were derived. A decrease in solubility for 1-butanol and 1-pentanol in the crowded media (HEPES + trehalose) was observed which is driven by a significant decrease in the favorable enthalpy of solution. The partial molar heat capacity, C-p,2(infinity) in each media was determined in our heat capacity drop calorimeter, also at 298.15 K. A significant decrease of the partial molar heat capacity was observed for both alcohols in (HEPES + trehalose), which together with the obtained decrease in favorable Delta H-sol(m), is consistent with a decrease in hydrophobic solvation, as a result of a decrease in free solvent availability induced by the trehalose. Finally, we tentatively predict that in the aqueous media of the crowded solutions that characterize cells and biological fluids, solutes with low aqueous solubility will be more soluble, whereas the solubility of highly polar solutes will be reduced.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9