Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of synthetic musk fragrances in aqueous matrices by gas chromatography-mass spectrometry

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Vera Homem (Author) FEUP; Alice Alves (Author) FEUP; Arminda Alves (Author) FEUP; Lúcia Santos (Author) FEUP

Journal

Title: Talanta

Vol. 148

Pages: 84-93

ISSN: 0039-9140

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 27 Citations

ISI Web of Science

Scopus - 44 Citations

Scientific classification

FOS: Engineering and technology

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

Authenticus ID: P-00G-T4S

DOI: 10.1016/j.talanta.2015.10.049

Abstract (EN): A rapid and simple method for the simultaneous determination of twelve synthetic musks in water samples, using ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) coupled with gas chromatography-mass spectrometry (GC-MS) was successfully developed. The influence of seven factors (volume of the extraction solvent and disperser solvent, sample volume, extraction time, ionic strength, type of extraction and disperser solvent) affecting the UA-DLLME extraction efficiency was investigated using a screening design. The significant factors were selected and optimised employing a central composite design: 80 mu L of chloroform, 880 mu L of acetonitrile, 6 mL of sample volume, 3.5% (wt) of NaCl and 2 min of extraction time. Under the optimised conditions, this methodology was successfully validated for the analysis of 12 synthetic musk compounds in different aqueous samples (tap, sea and river water, effluent and influent wastewater). The proposed method showed enrichment factors between 101 and 115 depending on the analyte, limits of detection in the range of 0.004-54 ng L-1 and good repeatability (most relative standard deviation values below 10%). No significant matrix effects were found, since recoveries ranged between 71% and 118%. Finally, the method was satisfactorily applied to the analysis of five different aqueous samples. Results demonstrated the existence of a larger amount of synthetic musks in waste-waters than in other water samples (average concentrations of 2800 ng L-1 in influent and 850 ng L-1 in effluent). Galaxolide, tonalide and exaltolide were the compounds most detected.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10