Understanding the composition-structure-bioactivity relationships in diopside (CaO center dot MgO center dot 2SiO(2))-tricalcium phosphate (3CaO center dot P2O5) glass system

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Saurabh Kapoor (Author) Other; Angela Semitela (Author) Other; Ashutosh Goel (Author) Other; Ye Xiang (Author) Other; Jincheng C Du (Author) Other; Ana H Lourenco (Author) Other; Daniela M Sousa (Author) Other; Pedro L Granja (Author) FEUP; Jose M F Ferreira (Author) Other

Journal

Title: Acta Biomaterialia

Vol. 15

Pages: 210-226

ISSN: 1742-7061

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-00A-6PZ

DOI: 10.1016/j.actbio.2015.01.001

Abstract (EN): The present work is an amalgamation of computation and experimental approach to gain an insight into composition-structure-bioactivity relationships of alkali-free bioactive glasses in the CaO-MgO-SiO2-P2O5 system. The glasses have been designed in the diopside (CaO center dot MgO center dot 2SiO(2); Di)-tricalcium phosphate (3CaO center dot P2O5; TCP) binary join by varying the Di/TCP ratio. The melt-quenched glasses have been investigated for their structure by molecular dynamic (MD) simulations as well as by nuclear magnetic resonance spectroscopy (NMR). In all the investigated glasses silicate and phosphate components are dominated by Q(2) (Si) and Q(0) (P) species, respectively. The apatite forming ability of the glasses was investigated using X-ray diffraction (XRD), infrared spectroscopy after immersion of glass powders in simulated body fluid (SBF) for time durations varying between 1 h and 14 days, while their chemical degradation has been studied in Tris-HCl in accordance with ISO 10993-14. All the investigated glasses showed good bioactivity without any substantial variation. A significant statistical increase in metabolic activity of human mesenchymal stem cells (hMSCs) when compared to the control was observed for Di-60 and Di-70 glass compositions under both basal and osteogenic conditions. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17