Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Engineering proteolytically-degradable artificial extracellular matrices
Publication

Publications

Engineering proteolytically-degradable artificial extracellular matrices

Title
Engineering proteolytically-degradable artificial extracellular matrices
Type
Another Publication in an International Scientific Journal
Year
2014
Authors
Keila B Fonseca
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Cristina C Barrias
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Vol. 39
Pages: 2010-2029
ISSN: 0079-6700
Publisher: Elsevier
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-009-Z9C
Abstract (EN): Hydrogels are widely used as provisional matrices for tissue engineering and regenerative medicine, showing also great promise as platforms for 3D cell culture. Different bio-functionalization strategies have been proposed to enhance the biological performance of hydrogels, particularly when they lack intrinsic bioactivity. In this context, the design of artificial materials that mimic structural and functional features of the natural extracellular matrix (ECM) has been pursued. This review presents an overview on bioengineering approaches of integrating protease-sensitive motifs into hydrogels, for the creation of cell-responsive biomimetic scaffolding materials that degrade in response to their proteolytic microenvironment The successful incorporation of protease-sensitive motifs in several synthetic and natural polymers, which has been achieved using various chemical routes, is described. In each case, the selected peptide sequences and their target proteases are highlighted, along with the main achievements of the study. A critical analysis of current limitations and recent advances is also provided, along with suggestions for further improvements. (C) 2014 Elsevier Ltd. All rights reserved.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 20
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same authors

Molecularly designed alginate hydrogels susceptible to local proteolysis as three-dimensional cellular microenvironments (2011)
Article in International Scientific Journal
Keila B Fonseca; Silvia J Bidarra; Maria J Oliveira; Pedro L Granja; Cristina C Barrias
Matrix-driven formation of mesenchymal stem cell-extracellular matrix microtissues on soft alginate hydrogels (2014)
Article in International Scientific Journal
Raquel R Maia; Keila B Fonseca; Gabriela Rodrigues; Pedro L Granja; Cristina C Barrias
Injectable MMP-Sensitive Alginate Hydrogels as hMSC Delivery Systems (2014)
Article in International Scientific Journal
Keila B Fonseca; David B Gomes; Kangwon Lee; Susana G Santos; Aureliana Sousa; Eduardo A Silva; David J Mooney; Pedro L Granja; Cristina C Barrias
Injectable in situ crosslinkable RGD-modified alginate matrix for endothelial cells delivery (2011)
Article in International Scientific Journal
Silvia J Bidarra; Cristina C Barrias; Keila B Fonseca; Mario A Barbosa; Raquel A Soares; Pedro L Granja
Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-20 at 04:20:19 | Privacy Policy | Personal Data Protection Policy | Whistleblowing