Copper(II) increases bile acid binding to asparagine

• Type: Article in International Scientific Journal
• Date: 1998

Authors

de Castro, B (Author) FCUP; Lima, JLFC (Author) FFUP; Mayer, IH (Author) Other; Reis, S (Author) FFUP

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 16

Pages: 771-776

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-001-9CQ

DOI: 10.1016/s0731-7085(97)00109-x

Abstract (EN): Interactions of two bile acids (cholic and glycocholic acids) with asparagine have been studied by potentiometry in aqueous solutions under conditions similar to those observed in biological fluids (37 degrees C and I = 0.15 M NaCl), and in the absence and presence of copper(II). To characterize the equilibria for the systems copper(II)/bile acid/asparagine, specifically to assess cooperative binding between bile acids and asparagine, the acidity constant of asparagine and formation constants for copper(ZI)/bile acid and copper(II)/asparagine were also obtained under the same conditions. The results obtained suggest cooperativity in the binding of bile acid to asparagine in the presence of copper(II). (C) 1998 Elsevier Science B.V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6