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Caffeic acid derivatives, analogs and applications: a patent review (2009-2013)

Title
Caffeic acid derivatives, analogs and applications: a patent review (2009-2013)
Type
Article in International Scientific Journal
Year
2014
Authors
Tiago Silva
(Author)
Other
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Catarina Oliveira
(Author)
Other
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Fernanda Borges
(Author)
FCUP
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Journal
Vol. 24
ISSN: 1354-3776
Publisher: Taylor & Francis
Scientific classification
FOS: Natural sciences > Chemical sciences
CORDIS: Physical sciences > Chemistry > Applied chemistry > Pharmaceutical chemistry
Other information
Authenticus ID: P-009-YEX
Abstract (EN): Introduction: Caffeic acid (CA) is broadly distributed in several species of the plant kingdom and is widely consumed in human diet. CA and derivatives have been extensively studied in the past years, which unveiled a broad spectrum of biological activities and potential therapeutic applications. As a result, there has been an upsurge in the development of new chemical entities based on the CA scaffold. Areas covered: The scope of this review is to revisit the therapeutic potential of CA and derivatives. It provides an overview of patented processes and applications thereof between 2009 and 2013. Expert opinion: The phenylpropanoid framework is currently considered a valid structure for drug discovery programs. Actually, CA has been widely used as a template for the development of new chemical entities with potential therapeutic interest in human diseases associated with oxidative stress. Additionally, the applicability of CA derivatives expands to the realms of cosmetic industry due to its stabilizing properties. The synthesis of esters, amides and hybrids with currently marketed drugs is a trending strategy for the development of derivatives with therapeutic application. It is our opinion that the innovative artwork currently being developed involving this chemical scaffold will yield new and effective therapeutic agents in a foreseeable future.
Language: English
Type (Professor's evaluation): Scientific
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