Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Jaleco, AC (Author) Other; Neves, H (Author) Other; Hooijberg, E (Author) Other; Gameiro, P (Author) Other; Clode, N (Author) Other; Haury, M (Author) Other; Henrique, D (Author) Other; Parreira, L (Author) Other

Journal

Title: Journal of Experimental Medicine

Vol. 194

Pages: 991-1001

ISSN: 0022-1007

Publisher: Rockefeller University Press

Indexing

ISI Web of Knowledge - 241 Citations

Scopus - 260 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-T5H

DOI: 10.1084/jem.194.7.991

Abstract (EN): Notch signaling is known to differentially affect the development of lymphoid B and T cell lineages, but it remains unclear whether such effects are specifically dependent on distinct Notch ligands. Using a cell coculture assay we observed that the Notch ligand Delta-1 completely inhibits the differentiation of human hematopoietic progenitors into the B cell lineage while promoting the emergence of cells with a phenotype of T cell/natural killer (NK) precursors. In contrast, Jagged-1 did not disturb either B or T cell/NK development. Furthermore, cells cultured in the presence of either Delta-1 or Jagged-1 can acquire a phenotype of NK cells, and Delta-1, but not Jagged-1, permits the emergence of a de novo cell population coexpressing CD4 and CD8. Our results thus indicate that distinct Notch ligands can mediate differential effects of Notch signaling and provide a useful system to further address cell-fate decision processes in lymphopoiesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11