PRIMARY LIVER-CANCER IN GENETIC HEMOCHROMATOSIS - A CLINICAL, PATHOLOGICAL, AND PATHOGENETIC STUDY OF 54 CASES

• Type: Article in International Scientific Journal
• Date: 1993

Authors

DEUGNIER, YM (Author) Other; GUYADER, D (Author) Other; CRANTOCK, L (Author) Other; LOPEZ, JM (Author) FMUP; TURLIN, B (Author) Other; YAOUANQ, J (Author) Other; JOUANOLLE, H (Author) Other; CAMPION, JP (Author) Other; LAUNOIS, B (Author) Other; HALLIDAY, JW (Author) Other; POWELL, LW (Author) Other; BRISSOT, P (Author) Other

Journal

Title: Gastroenterology

Vol. 104

Pages: 228-234

ISSN: 0016-5085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 155 Citations

Scopus - 201 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-NK6

Abstract (EN): Background: Although liver cancer arises frequently in the course of genetic hemochromatosis (GH), it has not been previously studied in a large series of patients with well-defined GH. Methods: The bioclinical and pathological data from 1 cholangiocarcinoma and 53 hepatocellular carcinomas (HCCs) complicating GH in 32 untreated and 22 de-ironed patients are reported. Results: This study (1) adds three new well-documented cases of HCC in noncirrhotic but only fibrotic hemochromatotic liver, (2) shows the high prevalence (83%) of proliferative and often dysplastic (70%) iron-free foci in the nontumorous liver of untreated patients, and (3) emphasizes the significant increase of cirrhosis (81% vs. 28%) and of associated noniron-related risk factors, mainly chronic alcoholism (48% vs. 25%) and tobacco smoking (50% vs. 18%) in patients with HCC compared with matched hemochromatotic patients without HCC. Conclusions: These data (1) suggest that iron-free foci may be markers of an early stage of HCC in GH and (2) supply the basis for defining a cost-effective policy for the screening of HCC in GH patients. © 1993 by the American Gastroenterological Association.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7