Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Granjo, E (Author) Other; Lima, M (Author) Other; Lopes, JM (Author) FMUP; Cunha, N (Author) Other; Teixeira, MD (Author) Other; Santos, F (Author) Other; Candeias, J (Author) Other; Resende, C (Author) Other; Santos, AH (Author) Other; Balanzategui, A (Author) Other; Orfao, A (Author) Other; Matutes, E (Author) Other

Journal

Title: British Journal of Haematology

Vol. 119

Pages: 629-633

ISSN: 0007-1048

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-M56

DOI: 10.1046/j.1365-2141.2002.03889.x

Abstract (EN): We report a case of Sezary syndrome with two abnormal CD4(+) T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than a true biclonal disease. The patient achieved a transient response with 2-deoxycoformycin, with a selective decrease of the larger/hyperploid T-cell population; later on, an increased representation of this T-cell population was observed concomitantly with clinical relapse.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5