Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus: A Close Linkage with Obesity and Length of the Disease

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Susana Coimbra (Author) Other; Jorge Brandao Proenca (Author) Other; Alice Santos Silva (Author) FFUP; Andmaria Joao Neuparth (Author) Other

Journal

Title: BioMed Research International

Vol. 2014

Pages: 1-8

ISSN: 2314-6133

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 33 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-009-NCR

DOI: 10.1155/2014/701915

Abstract (EN): Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology. We aim to study the relationship between aging and chemerin, adiponectin, and leptin levels in type 2 diabetes mellitus (T2DM). Age correlated positively with chemerin and leptin and inversely with adiponectin. Body mass index (BMI) correlated positively with leptin (in males) and chemerin and inversely with adiponectin. The patients with >= 65 years (n = 34) showed significantly higher leptin and chemerin and lower adiponectin levels than middle-aged (38-64 years) patients (n = 39) and controls (n = 20). After statistical adjustment for length of disease, there was a loss of significance, between T2DM groups, for adiponectin and, in female, for leptin. In the older group, BMI correlated with adiponectin and with leptin, but not with chemerin. Adiponectin and leptin levels in elderly T2DM patients seem to be closely linked to obesity and to length of the disease. In elderly T2DM patients, chemerin concentrations are increased and seem to be independent of length of disease and BMI, suggesting that adipocyte dysfunction is enhanced with aging. The understanding of the glucose homeostasis impairment in the elderly is mandatory in order to achieve ways to improve their quality of life and longevity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8