The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients With Type 2 Diabetes Mellitus

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Maria Joao Neuparth (Author) Other; Jorge Brandao Proenca (Author) Other; Alice Santos Silva (Author) FFUP; Susana Coimbra (Author) Other

Journal

Title: Journal of Investigative Medicine

Vol. 62

Pages: 350-353

ISSN: 1081-5589

Publisher: BMJ PUBLISHING GROUP

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 17 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-009-NAE

DOI: 10.231/jim.0000000000000025

Abstract (EN): Background: Physical exercise intervention is known to be crucial in the management of type 2 diabetes mellitus (T2DM). We aimed to evaluate, in patients with T2DM, the effect of regular moderate walking exercise on markers of oxidative stress, lipid metabolism, and inflammation. Methods: We studied 30 patients with T2DM who walked regularly during the last year and 53 patients with T2DM who did not perform any type of exercise. The patients were evaluated for chemerin, adiponectin, leptin, oxidized low-density lipoprotein, and C-reactive protein (CRP) levels. Results: The active T2DM patients showed significantly lower body mass index, as compared with the inactive patients. The active T2DM patients showed significantly lower levels of chemerin and CRP than those of the inactive T2DM patients (CRP lost significance after adjustment for body mass index). The active patients, compared with the inactive, presented a trend toward higher levels of adiponectin and lower values of oxidized low-density lipoprotein. Leptin differed significantly between sexes, and the active women presented a trend toward lower levels as compared with the inactive women. Conclusions: In the patients with T2DM, the practice of moderate walking in a regular basis was sufficient to reduce chemerin levels, which suggests that practice of regular physical exercise should be encouraged.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4