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The role of adipocytes in the modulation of iron metabolism in obesity

Title
The role of adipocytes in the modulation of iron metabolism in obesity
Type
Article in International Scientific Journal
Year
2013
Authors
Coimbra, S
(Author)
Other
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Catarino, C
(Author)
FFUP
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Santos Silva, A
(Author)
FFUP
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Journal
Title: Obesity ReviewsImported from Authenticus Search for Journal Publications
Vol. 14
Pages: 771-779
ISSN: 1467-7881
Publisher: Wiley-Blackwell
Scientific classification
FOS: Medical and Health sciences > Clinical medicine
Other information
Authenticus ID: P-006-6RS
Abstract (EN): A tight relationship between iron deficiency and obesity is known to exist. The chronic low-grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability. Adipose tissue is known to secret interleukin-6 and leptin that triggers hepcidin production. It was found that adipose tissue also expresses hepcidin and hemojuvelin, a regulator of hepcidin production. These recent findings suggest that adipose tissue may have an important role in erythropoiesis particularly on obesity that is still poorly clarified. This paper discusses these findings and how they can modulate erythropoiesis.
Language: English
Type (Professor's evaluation): Scientific
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