Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Belo, L (Author) FFUP; Caslake, M (Author) Other; Gaffney, D (Author) Other; Santos Silva, A (Author) FFUP; Pereira Leite, L (Author) Other; Quintanilha, A (Author) ICBAS; Rebelo, I (Author) FFUP

Journal

Title: Atherosclerosis

Vol. 162

Pages: 425-432

ISSN: 0021-9150

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 108 Citations

Scopus - 120 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-P3A

DOI: 10.1016/s0021-9150(01)00734-1

Abstract (EN): The aim of this study was to evaluate changes in lipids. apolipoproteins and lipoproteins in Portuguese pregnant women and their potential involvement in the pathophysiology of preeclampsia. A cross-sectional study was performed by collecting blood samples in the first (n=64), second (n=48) and third (n=67) trimesters and puerperium (n=32) of normal pregnancies. Samples from preeclamptic women were obtained in the third trimester (n=51) and in puerperium (n=26), As normal pregnancy progressed and triglyceride (TG) levels rose there as a decrease in lock density lipoprotein (LDL) size. as measured by peak and mean particle diameter (MPD), with in increased proportion of atherogenic small dense LDL. Preeclamptic women exhibited, in the third trimester and puerperium. higher mean serum TG concentration and lower high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) levels compared with healthy pregnant women. In the third trimester, LDL-mean particle diameter (LDL-MD) and LDL cholesterol-apolipoprotein B (LDLc-apo B) ratio were also significantly reduced in the pathologic group. We Conclude that human gestation is associated with an 'atherogenic' lipid profile that is further enhanced in preeclampsia and that this profile may be a potential contributor to endothelial cell dysfunction.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8