Red blood cell damage in normal and preeclamptic pregnancies: A study in maternal and umbilical cord blood

• Type: Article in International Conference Proceedings Book
• Date: 2005

Authors

Catarino, C (Author) FFUP; Rebelo, I (Author) FFUP; Rocha, S (Author) Other; Belo, L (Author) FFUP; Castro, E (Author) Other; Patricio, B (Author) Other; Quintanilha, A (Author) Other; Santos Silva, A (Author) FFUP

Conference proceedings International

Title: Proceedings of the 7th World Congress of Perinatal Medicine

Pages: 253-257

7th World Congress of Perinatal Medicine

Zagreb, CROATIA, SEP 21-24, 2005

Indexing

ISI Web of Knowledge - 0 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-6HM

Abstract (EN): Exposure of red blood cells (RBC) to oxygen metabolites produced by inflammatory cells may account for RBC damage, expressed by an increase in membrane bound haemoglobin (MBH) and by an abnormal band 3 profile. Our aim was to evaluate the maternal and fetal RBC damage in normal and preeclamptic (PEc) pregnancies, by studying band 3 profile and MBH. We found a significantly higher RBC damage in PE, as showed by higher MBH in pregnant women and in their sons, and by a different band 3 profile in the mothers. Moreover, we found that band 3 profile and MBH were significantly different for mothers and sons, suggesting a higher RBC damage in fetus. Our data suggest that an enhanced oxidative stress in PE mothers induces a higher RBC damage, which is also expressed in their PEc sons.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5