Taking tissue adhesives to the future: from traditional synthetic to new biomimetic approaches

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Ligia Pereira Bre (Author) Other; Yu Zheng (Author) Other; Ana Paula Pego (Author) FEUP; Wenxin X Wang (Author) Other

Journal

Title: Biomaterials Science

Vol. 1

Pages: 239-253

ISSN: 2047-4830

Publisher: Royal Society of Chemistry

Indexing

ISI Web of Knowledge - 43 Citations

Scopus - 70 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-008-AWR

DOI: 10.1039/c2bm00121g

Abstract (EN): Tissue adhesives are a versatile and valuable alternative for wound closure. With fast application, the prevention of body fluid leakage and additional trauma to the wound, adhesives are desirable, especially in friable tissues. Although several options are already in the market, these present some drawbacks, namely poor adhesion in wet substrates and toxicity. Here, the main adhesives both synthetic and biomimetic, commercially available and those still in research, are analyzed with a focus on their adhesion mechanisms. At present, the strongest adhesive able to replace sutures in skin wounds is cyanoacrylate based. However it is toxic and therefore cannot be used internally. More recently alternatives have emerged, with PEG-based adhesives being biocompatible but mainly used as tissue sealants due to their low strength. The most recent approaches under development try to mimic the adhesion strategies of several organisms, such as the extensively studied blue mussels, sandcastle worms, barnacles and geckos. Although no ideal results have been achieved so far, large improvements have been accomplished in the last decade and research is reaching to a new level where the results are starting to meet the needs for medical applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15