Molecular Recognition Force Spectroscopy: A New Tool to Tailor Targeted Nanoparticles

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Hugo Oliveira (Author) Other; Martina Rangl (Author) Other; Andreas Ebner (Author) Other; Barbara Mayer (Author) Other; Peter Hinterdorfer (Author) Other; Ana P Pego (Author) FEUP

Journal

Title: Small

Vol. 7

Pages: 1236-1241

ISSN: 1613-6810

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 12 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-002-RH6

DOI: 10.1002/smll.201002074

Abstract (EN): The density of targeting moieties in a nanoparticle-based gene-delivery system has been shown to play a fundamental role in its vectoring performance. Here, molecular recognition force spectroscopy is proposed as a novel screening tool to optimize the density of targeting moieties of functionalized nanoparticles towards attaining cell-specific interaction. By tailoring the nanoparticle formulation, the unbinding event probability between nanoparticles tethered to an atomic force microscopy tip and neuronal cells is directly correlated to the nanoparticle gene-vectoring capacity. Additionally, new insights into protein-receptor interaction are revealed. This novel approach opens new avenues in the field of nanomedicine.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6