The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives

• Type: Another Publication in an International Scientific Journal
• Date: 2006

Authors

Ribeiro, R (Author) Other; Lopes, C (Author) ICBAS; Medeiros, R (Author) ICBAS

Journal

Title: Prostate Cancer and Prostatic Diseases

Vol. 9

Pages: 19-24

ISSN: 1365-7852

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 37 Citations

Scopus - 41 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-N5B

DOI: 10.1038/sj.pcan.4500844

Abstract (EN): Obesity-associated prostate cancer (PCa) remains controversial, although most studies rely on body mass index evaluation, which is an indirect measure of fatness. Studies using body fat measurement and disease stratification according to PCa stage found stronger associations between obesity and PCa. Leptin is a pleiotrophic hormone mainly synthesized by adipocytes that acts in peripheral organs such as the prostate. This article reviews obesity-associated leptin's pathophysiological role in PCa progression. PCa development results from some known risk factors. Currently, there is enough evidence suggesting that leptin is an additional factor involved in advanced PCa occurrence, and obesity association with high-grade disease. Life-long exposure to genetic and/or environmental susceptibility factors that predispose to obesity and higher leptin levels may increase the risk for advanced PCa.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6