Endothelial nitric oxide synthase gene polymorphisms and genetic susceptibility to prostate cancer

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Medeiros, R (Author) Other; Morais, A (Author) Other; Vasconcelos, A (Author) Other; Costa, S (Author) Other; Pinto, D (Author) Other; Oliveira, J (Author) Other; Lopes, C (Author) ICBAS

Journal

Title: European Journal of Cancer Prevention

Vol. 11

Pages: 343-350

ISSN: 0959-8278

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 65 Citations

Scopus - 71 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-NEW

DOI: 10.1097/00008469-200208000-00005

Abstract (EN): The endothelial cell-specific form of nitric oxide synthases (ecNOS) is localized at 7q35-q36 and is involved in vascular development and tumour growth in human prostate cancer. We have conducted a case-control study to investigate the prevalence of two polymorphisms at intron 4 (ecNOS4a/b) and exon 7 (Glu-Asp298) of ecNOS gene in 125 prostate cancer (PCa) patients and in 153 controls. We observed that the a-allele (aa or ab genotypes from ecNOS4a/b) was over-presented in the group of PCa with Gleason histological grade greater than or equal to7 (P = 0.041). With regard to the Glu-Asp298 polymorphism, patients with the T-allele were younger than patients with no T-allele (P = 0.037), and a statistically significant difference was noted in the Glu-Asp298 genotype distribution between cases with advanced disease and cases with localized disease (P = 0.0013). When comparing cases and controls with logistic regression analysis we observed that the presence of the a-allele is associated with prostate cancer risk (odds ratio (OR) 1.83; 95% confidence interval (0) 1.06-3.17; P = 0.029), to high histological grade (Gleason greater than or equal to7) of PCa (OR 2.18; 95% CI 0.95-4.98; P = 0.062) and with the risk of progression of the cancer disease (OR 2.85; 95% CI 1.19-6.82; P = 0.018). Furthermore, we found that carriers with the combination of the a-allele (aa and ab ecNOS4a/b genotypes) and T-allele (GT and TT from Glu-Asp298) have a threefold increase in prostate cancer risk (OR 3.13; 95% CI 1.41-6.91, P = 0.004). In summary, we have identified an NO-related genetic risk factor for prostate cancer that may help in understanding the molecular mechanism involved in the individual susceptibility to prostate cancer. (C) 2002 Lippincott Williams Wilkins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8