The CYP3A4*1B polymorphism and prostate cancer susceptibility in a Portuguese population

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana Nogal (Author) Other; Ana Coelho (Author) Other; Raquel Catarino (Author) Other; Antonio Morais (Author) Other; Francisco Lobo (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 177

Pages: 149-152

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-7MT

DOI: 10.1016/j.cancergencyto.2007.06.011

Abstract (EN): Testosterone exposure has been implicated in prostate carcinogenesis, and genes that alter its metabolism, such as CYP3A4, have been associated with prostate cancer susceptibility. The aim of our study was to assess the relationship between the CYP3A4*1B polymorphism and its possible role in the development of prostate cancer. DNA samples obtained from the peripheral blood cells of 414 individuals diagnosed with prostate cancer and 337 healthy male donors were used in this case-control study. The CYP3A4*1B polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism methodology. We found no statistically significant differences in the distribution of the CYP3A4*1B genotypes between cases and controls (P = 0.470; odds ratio = 1.191; 95% confidence interval =0.740-1.918), as well as after the stratification of our analysis, according to important clinicopathologic parameters of prostate cancer. Our results suggest that the CYP3A4*]B polymorphism is not associated with prostate cancer risk within the Portuguese population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4