Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Linkage between Polymorphisms in the prostate specific antigen AREI gene region, prostate cancer risk, and circulating tumor cells
Publication

Publications

Linkage between Polymorphisms in the prostate specific antigen AREI gene region, prostate cancer risk, and circulating tumor cells

Title
Linkage between Polymorphisms in the prostate specific antigen AREI gene region, prostate cancer risk, and circulating tumor cells
Type
Article in International Scientific Journal
Year
2002
Authors
Medeiros, R
(Author)
Other
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Morais, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Vasconcelos, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Costa, S
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Pinto, D
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Oliveira, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Carvalho, R
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Lopes, C
(Author)
ICBAS
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page Without ORCID
Journal
Title: ProstateImported from Authenticus Search for Journal Publications
Vol. 53
Pages: 88-94
ISSN: 0270-4137
Publisher: Wiley-Blackwell
Scientific classification
FOS: Medical and Health sciences > Clinical medicine
Other information
Authenticus ID: P-000-MZR
Abstract (EN): BACKGROUND. The prostate specific antigen (PSA) gene has a polymorphic androgen response element (ARE) sequence with two alleles, A and G. PSA A-allele carriers have higher serum PSA levels in healthy men (HM). METHODS. We analysed DNA samples from 278 (556 alleles) unrelated individuals, 127 HM and 151 prostate cancer (PC) patients, for PSA ARE1 genotypes. RESULTS. The analysis of the frequencies from the 556 alleles indicates a significant over-representation of A-allele in the PC group under the age of 67 compared with the HM group (63.3% vs. 48.8%; P = 0.009). We found that men carrying two A-alleles have increased risk for PC onset under the age of 67 (odds ratio [OR] = 2.92; 95% confidence interval [CI], 1.10-7.86; P = 0.013). Multivariate logistic regression analysis confirmed this association (OR = 1.82; 95% CI, 1.03-3.22; P = 0.037). Furthermore, the homozygosity for the A-allele was associated with higher serum PSA levels (P = 0.027) and with the presence of circulating tumor cells in the blood of PC patients (P = 0.018). CONCLUSION. Our results indicate that polymorphism in the PSA gene promoter may be an important biomarker for prostate cancer risk, especially for an earlier onset of PC. (C) 2002 Wiley-Liss, Inc.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 7
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Prediction of Individual Genetic Risk to Prostate Cancer Using a Polygenic Score (2015)
Article in International Scientific Journal
Szulkin, R; Whitington, T; Eklund, M; Aly, M; Eeles, RA; Easton, D; Kote-Jarai, Z; Amin Al Olama, A; Benlloch, S; Muir, K; Giles, GG; Southey, MC; Fitzgerald, LM; Henderson, BE; Schumacher, F; Haiman, CA; Schleutker, J; Wahlfors, T; Tammela, TL; Nordestgaard, BG...(mais 43 authors)
Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease (2004)
Article in International Scientific Journal
Ribeiro, R; Vasconcelos, A; Costa, S; Pinto, D; Morais, A; Oliveira, J; Lobo, F; Lopes, C; Medeiros, R
Metabolic susceptibility genes and prostate cancer risk in a southern European population: The role of glutathione S-transferases GSTM1,GSTM3, and GSTT1 genetic polymorphisms (2004)
Article in International Scientific Journal
Medeiros, R; Vasconcelos, A; Costa, S; Pinto, D; Ferreira, P; Lobo, F; Morais, A; Oliveira, J; Lopes, C
Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population (2005)
Article in International Scientific Journal
Costa, I; Pinto, D; Morais, A; Vasconcelos, A; Oliveira, J; Lopes, C; Medeiros, R
Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-10 at 11:24:02 | Privacy Policy | Personal Data Protection Policy | Whistleblowing