HLA-DRB1 and susceptibility/ resistence to cervical Neoplasia in Portuguese women

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Pinto, D (Author) Other; Medeiros, R (Author) Other; Vasconcelos, A (Author) Other; Casimiro, S (Author) Other; Costa, I (Author) Other; Pinto, IM (Author) Other; Porto, T (Author) Other; Lopes, C (Author) Other; Martins Da Silva, B (Author) Other; Moutinho, J (Author) Other

Journal

Title: European Journal of Immunogenetics

Vol. 28

Final page: 306

ISSN: 0960-7420

Publisher: Blackwell

Indexing

ISI Web of Knowledge

Scopus - 0 Citations

Other information

Authenticus ID: P-007-G94

Abstract (EN): Carcinoma of the cervix is the third most common type of cancer among Portuguese women and is frequently associated with high-risk human papillomavirus (HPV) types. The host immune response to HPVs is believed to be an important determinant of development and progression of papillomavirus-associated neoplasias. Given the HLA role in viral peptide presentation during immune response, the host genetic variation may influence susceptibility and resistance to HPV-associated neoplasias. Recent studies suggest an association between certain HLA class-II alleles and HPV-associated lesions, but these observations are still controversial. To further evaluate this issue, a search for a relationship between HLA-DQB1 and -DRB1 alleles, HPV types and precursor lesions of cervical carcinoma in Portuguese women was undertaken. HLA typing was performed by PCR-SSP DNA amplification on cervical scrapes from 40 women (30 with high-grade squamous intraepithelial lesions (SIL) and 10 with low-grade SIL) and peripheral blood lymphocytes from 240 healthy control subjects. The presence and typing of HPV were determined by PCR with specific primers. A slight increase of DRB1*11 (30.6% vs. 18.7% in controls) and decrease of DRB1* 13 (16.7% vs. 23.7% in controls) frequencies were observed in SIL patients, irrespective of the HPV type, suggesting that these specific HLA antigens may be important in determining the risk of SIL. A significant decrease in DRB1*04 frequency was found in SIL cases comparing with the control panel (p=0.022; OD=0.30, 95% confidence interval=0.09-0.95). The association between SIL and DQB1*03 allele, described for cervical carcinoma in some populations, was not observed in the present study. In conclusion, our preliminary results suggest a protective effect of HLA-DRB1*04 against HPV-associated SIL of the cervix. © 2001 Blackwell Science Ltd,.

Language: English

Type (Professor's evaluation): Scientific