Localization of Candidate Genes in a Region of High Frequency of Microvariant Alleles for Prostate Cancer Susceptibility: The Chromosome Region Yp11.2 Genetic Variation

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Raquel Carvalho (Author) Other; Maria Fatima Pinheiro (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: DNA and Cell Biology

Vol. 29

Pages: 3-7

ISSN: 1044-5498

Publisher: Mary Ann Liebert

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-003-AKM

DOI: 10.1089/dna.2009.0905

Abstract (EN): The Y chromosome has been suggested to play a role in prostate cancer (PCa) because the loss of this chromosome is the most common aberration in PCa. Study of short tandem repeats (STRs) could provide a means to rapidly scan genomes at known or unknown predisposing loci for some diseases. DNA samples from 281 patients with PCa at the Portuguese Institute of Oncology, Porto, Portugal, and a population control of 175 healthy controls were analyzed for region Yp11.2 using AmpFlSTR (R) Y-Filer (TM) kit (Applied Biosystems). The results demonstrated that microvariant alleles of DYS458 are overrepresented (p = 0.026). We found that allele 12 of DYS393 and allele 19 of DYS458 could have a protective effect (p = 0.0051; odds ratio [OR] = 0.48; 95% confidence interval [95% CI] 0.27-0.38; and p = 0.0272; OR = 0.47; 95% CI 0.22-0.98). On the other hand, patients carrying allele 13 of DYS393 presented an increased risk to PCa (p = 0.015; OR = 1.97; 95% CI 1.26-3.07). These results are in concordance with the involvement of Y chromosome in PCa development. STR allele studies may add further information from the definition of a genetic profile of PCa resistance or susceptibility. As TSPY is located at region Yp11.2, this gene could play an essential role in PCa development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5