TP73 alterations in cervical carcinoma

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Craveiro, R (Author) Other; Costa, S (Author) Other; Pinto, D (Author) Other; Salgado, L (Author) Other; Carvalho, L (Author) Other; Castro, C (Author) Other; Bravo, I (Author) Other; Lopes, C (Author) ICBAS; Silva, I (Author) Other; Medeiros, R (Author) ICBAS

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 150

Pages: 116-121

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 27 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-AST

DOI: 10.1016/j.cancergencyto.2003.08.020

Abstract (EN): Infection with human papillomaviruses (HPV) is essential in the carcinogenesis of the uterine cervix. However, a complex interrelation between viral and cellular genes is necessary for cell-cycle control deregulation and development and progression of cervical cancer induction. The TP73 gene is localized in I p36.3 band, which is often deleted by loss of heterozygosity (LOH) in human cancers. We analyzed the p73 cytosine thymine polymorphism and LOH in this locus by polymerase chain reaction restriction fragment length polymorphism in 134 DNA samples from biopsies of 67 primary untreated invasive cervix tumors and the corresponding peripheral blood. Genotype frequencies of 56.7% for homozygous genotype GC/GC and 43.3% for heterozygous genotype GC/AT were found. The presence of the GUAT genotype in tumors was associated with lower age at menarche (P = 0.039) and high parity (P = 0.015). In 20.0% of DNA tumor samples, the AT allele was lost compared with their DNA normal blood pairs. The AT allele was conserved in women with high parity. This was not the case in the group with low parity, with 33.3% of patients showing loss of the AT allele in tumor DNA (P = 0.041). These results suggest that TP73 genetic alterations may contribute to the genesis and/or progression of cervical carcinoma in an HPV-infected transformation zone under prolonged exposure to events related to pregnancy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6