Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Souto, EB (Author) Other; Wissing, SA (Author) Other; Barbosa, CM (Author) FFUP; Muller, RH (Author) Other

Journal

Title: International Journal of Pharmaceutics

Vol. 278

Pages: 71-77

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 434 Citations

Scopus - 539 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-9XR

DOI: 10.1016/j.ijpharm.2004.02.032

Abstract (EN): Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many Substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40degreesC. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7