The insular cortex controls food preferences independently of taste receptor signaling

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Oliveira Maia, AJ (Author) Other; de Araujo, IE (Author) Other; Monteiro, C (Author) Other; Workman, V (Author) Other; Galhardo, V (Author) FMUP; Nicolelis, MAL (Author) Other

Journal

Title: Frontiers in Systems Neuroscience

Vol. 6

ISSN: 1662-5137

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge

Scopus - 23 Citations

Other information

Authenticus ID: P-008-2X8

DOI: 10.3389/fnsys.2012.00005

Abstract (EN): The insular cortex (IC) contains the primary sensory cortex for oral chemosensation including gustation, and its integrity is required for appropriate control of feeding behavior. However, it remains unknown whether the role of this brain area in food selection relies on the presence of peripheral taste input. Using multielectrode recordings, we found that the responses of populations of neurons in the IC of freely licking, sweet-blindTrpm5 -/- mice are modulated by the rewarding postingestive effects of sucrose. FOS immunoreactivity analyses revealed that these responses are restricted to the dorsal insula. Furthermore, bilateral lesions in this area abolished taste-independent preferences for sucrose that can be conditioned in theseTrpm5 -/- animals while preserving their ability to detect sucrose. Overall, these findings demonstrate that, even in the absence of peripheral taste input, IC regulates food choices based on postingestive signals. © 12 Oliveira-Maia.

Language: English

Type (Professor's evaluation): Scientific