Recombinant human erythropoietin doping in sports - cardiovascular effects in chronic and acute aerobic exercise in an animal model

• Type: Article in International Conference Proceedings Book
• Date: 2009

Authors

Piloto, N (Author) Other; Reis, F (Author) Other; Teixeira, HM (Author) Other; Teixeira Lemos, E (Author) Other; Parada, B (Author) Other; Garrido, P (Author) Other; Sereno, J (Author) Other; Costa, E (Author) FFUP; Pinto, R (Author) Other; Pinto, AF (Author) Other; Ferreira, L (Author) Other; Rocha Pereira, R (Author) Other; Belo, L (Author) FFUP; Santos Silva, A (Author) FFUP; Teixeira, F (Author) Other

Conference proceedings International

Title: 9TH CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS - EACPT

Pages: 181-185

9th Congress of the European-Association-for-Clinical-Pharmacology-and-Therapeutics (EACPT)

Edinburgh, SCOTLAND, JUL 12-15, 2009

Indexing

ISI Web of Knowledge - 0 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-T0V

Abstract (EN): Compare the cardiovascular effects of rhEPO on rats under chronic vs acute exercise. Chronic exercise (swimming: swi) in male rats for 10 wks: control - sedentary (SED): rhEPO - 50 IU/Kg/wk: swimming (EX) - 1 hr, 3 times/wk; EX+EPO. For the extenuating exercise (rhEPO given for 3 wks prior exercise): swi (Swi); Swi+EPO; running (Rum): Run+EPO. The chronic EX+EPO rats showed higher values of RBC. Htc and Hb vs EX and vs Swi+EPO of the acute sessions. Both chronic and acute swimming showed a remarkable sympathetic and serotonergic activation. rhEPO treatment in chronic training has promoted oxidative stress, in contrast with the antioxidant effect on Swi and Run of acute exercises. rhEPO doping is more deleterious in rats mimicking trained athletes (chronic) than in occasional abusers (acute), due to increased CV risk.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5