Erythropoiesis versus inflammation in Hereditary Spherocytosis clinical outcome

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Susana Rocha (Author) FFUP; Elisio Costa (Author) FFUP; Petronila Rocha Pereira (Author) Other; Fatima Ferreira (Author) Other; Esmeralda Cleto (Author) Other; Jose Barbot (Author) Other; Alexandre Quintanilha (Author) ICBAS; Luis Belo (Author) FFUP; Alice Santos Silva (Author) FFUP

Journal

Title: Clinical Biochemistry

Vol. 44

Pages: 1137-1143

ISSN: 0009-9120

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Scientific classification

FOS: Engineering and technology > Medical engineering

Other information

Authenticus ID: P-007-ZPG

DOI: 10.1016/j.clinbiochem.2011.06.006

Abstract (EN): Objectives: This study aimed to evaluate the relationship between erythropoiesis and inflammation, in Hereditary Spherocytosis (HS) clinical outcome. Design and methods: We studied 26 controls and 82 HS patients presenting mild (n = 49) and severer (n = 33) HS forms. We evaluated plasma levels of EPO, sTfR, ferritin, iron, folic acid, vitamin B12, TNF-alpha, IFN-gamma, elastase and lactoferrin; leukocyte and reticulocyte counts and RPI were determined. Results: All HS patients showed significantly higher EPO, sTfR, reticulocytes and RPI but only mild HS presented normal hemoglobin levels; the positive significant correlations between EPO and sTfR, reticulocytes and RPI observed in mild HS were not observed in severer HS patients. HS patients presented with higher levels of neutrophils, TNF-alpha, IFN-gamma, elastase, lactoferrin and ferritin. Conclusions: Our data show HS as a disease linked to enhanced erythropoiesis that is disturbed in the more severe forms, to which inflammation may contribute, at least in part.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7