Transient erythroblastopenia in the context of Epstein-Barr virus infection [Eritroblastopenia transitoria en el contexto de infección por el virus de Epstein-Barr]

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Sameiro Barreirinho, M (Author) Other; Lopes Guerra, M (Author) Other; Sousa Costa, E (Author) FFUP; Couceiro, AM (Author) Other; Rodrigues Neves, E (Author) Other; Morais Barbot, J (Author) Other

Journal

Title: Anales Espanoles de Pediatria

Vol. 56

ISSN: 0302-4342

Publisher: Doyma

Indexing

ISI Web of Knowledge

Scopus - 0 Citations

Scientific classification

FOS: Medical and Health sciences

Other information

Authenticus ID: P-007-A1V

Abstract (EN): The authors report the case of a previously healthy 5-year-old boy who, 1 month after tonsillitis, presented severe aregenerative anemia, macrocytosis, and increased hemoglobin F associated with mild thrombocytopenia. Peripheral blood smear showed no significant alterations and bone marrow aspirate revealed markedly decreased red blood cell precursors. Etiological investigation showed elevated titers of Epstein-Barr virus antibodies (IgM anti-viral capsid antigen). Bone marrow biopsy showed no criteria for red cell aplasia and in situ hybridization revealed intracellular Epstein-Barr virus. Reticulocytosis emerged from days 10-17 of follow-up, together with rising hemoglobin. Mean corpuscular volume and hemoglobin F returned to normal 2 months later. Immunological study revealed partial IgG3 deficit that persisted after 1 year of follow-up.

Language: Spanish

Type (Professor's evaluation): Scientific