Vascular access versus the effect of statins on inflammation and fibrinolysis in renal dialysis patients

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Maria do Sameiro Faria (Author) Other; Sandra Ribeiro (Author) Other; Petronila Rocha Pereira (Author) Other; Vasco Miranda (Author) Other; Alexandre Quintanilha (Author) Other; Flavio Reis (Author) Other; Elisio Costa (Author) FFUP; Luis Belo (Author) FFUP; Alice Santos Silva (Author) FFUP

Journal

Title: Journal of Vascular Access

Vol. 14

Pages: 335-341

ISSN: 1129-7298

Publisher: WICHTIG PUBLISHING

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-008-J93

DOI: 10.5301/jva.5000132

Abstract (EN): Purpose: The aim of this work was to assess the effect of statin therapy on inflammatory and fibrinolytic/endothelial (dys) function markers in end-stage renal disease (ESRD) patients under hemodialysis (HD), according to the type of vascular access. Methods: This transversal study includes 191 ESRD patients under regular HD, divided into four groups according to vascular access and statin therapy: 87 patients with arteriovenous fistula (AVF) and no statins (AVF-NS), 61 with AVF and statins (AVF-S), 27 with central venous dialysis catheter (CVC) and no statins (CVC-NS) and 16 with CVC and statins (CVC-S). The basic lipid profile and fibrinolytic/endothelial cell function markers were assessed. Results: Patients with CVC presented significantly higher levels of D-dimers compared with AVF groups. CVC-NS patients also presented the highest IL-6 values, which were significantly higher than those presented by CVC-S patients. AVF-S patients presented significantly higher t-PA and PAI-1 values and lower adiponectin levels compared with AVF-NS. Conclusions: Our results demonstrate that patients with CVC, particularly those not under statin therapy, present a higher production and turnover of fibrin. We also found that statin therapy decreases inflammation in CVC patients but is associated with a reduction of adiponectin and increased endothelial function marker levels in AVF patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7