Effect of hydroxypropyl methycellulose and hydrogenated castor oil on naproxen release from sustained-release tablets

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Amaral, MH (Author) FFUP; Sousa Lobo, JM (Author) Other; Ferreira, DC (Author) FFUP

Journal

Title: AAPS PharmSciTech

Vol. 2

ISSN: 1530-9932

Publisher: Springer Nature

Indexing

ISI Web of Knowledge

Scopus - 38 Citations

Other information

Authenticus ID: P-007-C3D

Abstract (EN): The effect of the concentration of hydrophilic (hydroxypropyl methylcellulose [HPMC]) and hydrophobic (hydrogenated castor oil [HCO]) products, fillers (lactose and dibasic calcium phosphate), and buffers (sodium bicarbonate, calcium carbonate, and sodium citrate) on naproxen release rate was studied. Matrix tablets were prepared by double compression, and In vitro dissolution tests were performed. The dissolution results showed that an increased amount of HPMC or hydrogenated castor oil resulted in reduced drug release. The inclusion of buffers in the HPMC matrix tablets enhanced naproxen release. For HCO tablets, only sodium bicarbonate enhanced naproxen release. The presence of lactose on HPMC matrix tablets did not show a significantly different result from that obtained with the formulation containing dibasic calcium phosphate as a filler. However, for the tablets containing HCO, the presence of lactose significantly enhanced the naproxen release rate. The matrix-forming materials in this study were suitable for use in sustained-release tablets containing naproxen. The drug release can be modulated by adding suitable amounts of diluents and buffers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8