Naproxen availability from variable-dose and weight sustained-release tablets

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Amaral, MH (Author) FFUP; Lobo, JMS (Author) Other; Ferreira, DC (Author) FFUP

Journal

Title: Drug Development and Industrial Pharmacy

Vol. 27 No. 8

Pages: 221-225

ISSN: 0363-9045

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-X0M

DOI: 10.1081/ddc-100000240

Abstract (EN): The aim of this work was to compare the naproxen availability from hydroxypropyl methylcellulose (HPMC) matrix tablets containing the same dose and a 2-fold weight variation (160 mg of naproxen in tablets weighting 250 and 500 mg) or with the same weight and a 2-fold dose variation (500 mg of weight and 160 or 320 mg of naproxen). The 2-fold weight variation in tablets with the same dose and also the 2-fold dose variation in tablets with the same weight did not affect the naproxen release. In addition, the release rate of two tablets of the same formulation and one tablet with a 2-fold dose and weight variation was not significantly different at the first minutes of the dissolution assay.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5