Solid lipid nanoparticles (SLN) - based hydrogels as potential carriers for oral transmucosal delivery of Risperidone: Preparation and characterization studies

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Silva, AC (Author) Other; Amaral, MH (Author) FFUP; Gonzalez Mira, E (Author) Other; Santos, D (Author) Other; Ferreira, D (Author) FFUP

Journal

Title: Colloids and Surfaces B: Biointerfaces

Vol. 93

Pages: 241-248

ISSN: 0927-7765

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 81 Citations

Scopus - 85 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-002-ATG

DOI: 10.1016/j.colsurfb.2012.01.014

Abstract (EN): Two different solid lipid nanoparticles (SLN)-based hydrogels (HGs) formulations were developed as potential mucoadhesive systems for risperidone (RISP) oral transmucosal delivery. The suitability of the prepared semi-solid formulations for application on oral mucosa was assessed by means of rheological and textural analysis, during 30 days. Plastic flows with thixotropy and high adhesiveness were obtained for all the tested systems, which predict their success for the oral transmucosal application proposed. The SLN remained within the colloidal range after HGs preparation. However, after 30 days of storage, a particle size increase was detected in one type of the HGs formulations. In vitro drug release studies revealed a more pronounced RISP release after SLN hydrogel entrapment, when compared to the dispersions alone. In addition, a pH-dependent release was observed as well. The predicted in vivo RISP release mechanism was Fickian diffusion alone or combined with erosion.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8