Cell-based in vitro models for predicting drug permeability

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Bruno Sarmento (Author) Other; Fernanda Andrade (Author) Other; Sara Baptista da Silva (Author) Other; Francisca Rodrigues (Author) Other; Jose das Neves (Author) Other; Domingos Ferreira (Author) FFUP

Journal

Title: Expert Opinion on Drug Metabolism and Toxicology

Vol. 8

Pages: 607-621

ISSN: 1742-5255

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 82 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-AP8

DOI: 10.1517/17425255.2012.673586

Abstract (EN): Introduction: In vitro cell models have been used to predict drug permeation in early stages of drug development, since they represent an easy and reproducible method, allowing the tracking of drug absorption rate and mechanism, with an advantageous cost-benefit ratio. Such cell-based models are mainly composed of immortalized cells with an intrinsic ability to grow in a monolayer when seeded in permeable supports, maintaining their physiologic characteristics regarding epithelium cell physiology and functionality. Areas covered: This review summarizes the most important intestinal, pulmonary, nasal, vaginal, rectal, ocular and skin cell-based in vitro models for predicting the permeability of drugs. Moreover, the similitude between in vitro cell models and in vivo conditions are discussed, providing evidence that each model may provisionally resemble different drug absorption route. Expert opinion: Despite the widespread use of in vitro cell models for drug permeability and absorption evaluation purposes, a detailed study on the properties of these models and their in vitro-in vivo correlation compared with human data are required to further use in order to consider a future drug discovery optimization and clinical development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15