Tetracycline, oxytetracycline and chlortetracycline complexation with copper (II). Potentiometric study [Complexação da tetraciclina, da oxitetraciclina e da clortetraciclina com o catião cobre (II). Estudo potenciométrico]

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Couto, CMCM (Author) Other; Montenegro, MCBS (Author) FFUP; Reis, S (Author) FFUP

Journal

Title: Quimica Nova

Vol. 23

Pages: 457-460

ISSN: 0100-4042

Publisher: Sociedade Brasileira de Quimica

Indexing

ISI Web of Knowledge

Scopus - 16 Citations

Other information

Authenticus ID: P-007-BSY

Abstract (EN): Stability constants of complexes formed by copper (II) with three different tetracyclines (tetracycline, oxytetracycline and chlortetracycline) have been determined potentiometrically with an automatic system in aqueous medium at 25,0 ± 0,2 °C and I = 0,1 mol L-1 NaNO3. The protonation constants of the three tetracyclines were also determined under the same conditions. The distribution of the complexes was then simulated at therapeutic levels of the drugs.

Language: Portuguese

Type (Professor's evaluation): Scientific