Abstract (EN):
Stability constants of complexes formed by copper (II) with three different tetracyclines (tetracycline, oxytetracycline and chlortetracycline) have been determined potentiometrically with an automatic system in aqueous medium at 25,0 +/- 0,2 degrees C and I = 0,1 mol L-1 NaNO3. The protonation constants of the three tetracyclines were also determined under the same conditions, The distribution of the complexes was then simulated at therapeutic levels of the drugs.
Language:
Portuguese
Type (Professor's evaluation):
Scientific
No. of pages:
4