Multi-task flow system for potentiometric analysis: its application to the determination of vitamin B-6 in pharmaceuticals

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Fernandes, RN (Author) Other; Sales, MGF (Author) Other; Reis, BF (Author) Other; Zagatto, EAG (Author) Other; Araujo, AN (Author) FFUP; Montenegro, MCBSM (Author) FFUP

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 25

Pages: 713-720

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 34 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-V3F

DOI: 10.1016/s0731-7085(00)00581-1

Abstract (EN): A flow set-up based on the sequential injection analysis concept was designed. aiming at increased automation and robustness of procedures related with potentiometric detection in pharmaceutical control. In this sense, programmable set-up calibration, ion-selective electrode characterization, standard addition techniques and titration procedures could be carried out without any stock solutions conventional handling or modification on the physical structure of the flow system. Evaluation of a flow-through vitamin B-6 selective electrode and its application to routine analysis of pharmaceuticals were selected as models to demonstrate the: System potentialities, The system ability to generate in-line calibrating solutions was verified by comparing the results with those obtained with solutions prepared by the manual procedure. The vitamin B, determination in pharmaceutical products was carried out and in-line performed recoveries gave values within 97.4-103.5%. The system ability to perform titrations was ascertained using the precipitation reaction of vitamin B, with tetraphenylborate. Other profitable features such as lower reagent consumption with a low effluent generation volume were also achieved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8