Comparative study of sustained-release lipid microparticles and solid dispersions containing ibuprofen

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Hugo Almeida (Author) Other; Maria Helena Amaral (Author) FFUP; Paulo Lobao (Author) FFUP

Journal

Title: Brazilian Journal of Pharmaceutical Sciences

Vol. 48

Pages: 529-536

ISSN: 1984-8250

Publisher: Universidade de São Paulo

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 10 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-84W

DOI: 10.1590/s1984-82502012000300020

Abstract (EN): Ibuprofen is one of the most important non-steroidal anti-inflammatory drugs used in the treatment of inflammatory diseases. In its pure state, ibuprofen presents poor physical and mechanical characteristics and its use in solid dosage forms needs the addition of excipients that improve these properties. The selection of the best excipients and the most suitable pharmaceutical dosage form to carry ibuprofen is very important for the industrial success of this drug. Given these factors, lipid microparticles and solid dispersions of ibuprofen with cetyl alcohol, stearic acid, and hydrogenated castor oil were prepared. These formulations were intended to improve the physical and mechanical characteristics and to sustain the release of this drug. Physical mixtures were also prepared with the same ingredients in similar proportions. The solid dispersions of ibuprofen/stearic acid and ibuprofen/hydrogenated castor oil showed the best flow characteristics compared with pure ibuprofen. Further, gelatin capsules filled with lipid microparticles and solid dispersions were submitted to dissolution tests in order to study the influence of the prepared systems in the release profiles of ibuprofen. Prolonged release of ibuprofen was achieved with the lipid microparticles and solid dispersions prepared with the different types of excipients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8