Characterization, sensorial evaluation and moisturizing efficacy of nanolipidgel formulations

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Estanqueiro, M (Author) Other; Conceicao, J (Author) Other; Amaral, MH (Author) FFUP; Sousa Lobo, JMS (Author) Other

Journal

Title: International Journal of Cosmetic Science

Vol. 36

Pages: 159-166

ISSN: 0142-5463

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 23 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Technological sciences > Technology > Pharmaceutical technology

Other information

Authenticus ID: P-009-7TE

DOI: 10.1111/ics.12109

Abstract (EN): SynopsisBackground Nanostructured lipid carriers (NLC) have been widely studied for cosmetic and dermatological applications due to their favourable properties that include the formation of an occlusive film on the skin surface that reduces the transepidermal water loss (TEWL) and increase in water content in the skin which improves the appearance on healthy human skin and reduces symptoms of some skin disorders like eczema. Objective The main objective of this study was the development of semisolid formulations based NLC with argan oil or jojoba oil as liquid lipids, by addition of Carbopol((R))934 or Carbopol((R))980 as gelling agents, followed by comparison between instrumental analysis and sensorial evaluation and in vivo efficacy evaluation. Methods Nanostructured lipid carriers dispersions were produced by the ultrasound technique, and to obtain a semisolid formulation, gelling agents were dispersed in the aqueous dispersion. Particle size, polydispersity index and zeta potential were determined. Instrumental characterization was performed by rheological and textural analysis; the sensorial evaluation was also performed. Finally, skin hydration and TEWL were studied by capacitance and evaporimetry evaluation, respectively. Results Particles showed a nanometric size in all the analysed formulations. All the gels present pseudoplastic behaviour. There is a correspondence between the properties firmness and adhesiveness as determined by textural analysis and the sensory evaluation. The formulations that showed a greater increase in skin hydration also presented appropriate technological and sensorial attributes for skin application. Conclusions Nanolipidgel formulations with the addition of humectants are promising systems for cosmetic application with good sensory and instrumental attributes and moisturizing efficacy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8