Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: Clinical, immunological and cytogenetic features and therapeutic approach - A case report

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Granjo, E (Author) Other; Lima, M (Author) Other; Lopes, JM (Author) FMUP; Doria, S (Author) FMUP; Orfao, A (Author) Other; Ying, S (Author) Other; Barata, LT (Author) Other; Miranda, M (Author) Other; Cross, NCP (Author) Other; Bain, BJ (Author) Other

Journal

Title: Acta Haematologica

Vol. 107

Pages: 108-112

ISSN: 0001-5792

Publisher: Karger

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 23 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-QMZ

DOI: 10.1159/000046640

Abstract (EN): A 23-year-old, white male metallurgist presented with pruritic erythematous maculo-papules over the trunk and upper limbs and 6 months later developed erythroderma, eosinophilia and multi-organ dysfunction. A diagnosis of chronic eosinophilic leukaemia was made on the basis of myeloproliferative involvement of both peripheral blood and bone marrow, associated with eosinophilic differentiation and a t(5;12)(q33;p13) translocation. The initial therapeutic approach was interferon alfa-2b plus cytosine arabinoside, for 13 months, followed by hydroxyurea plus vincristine. There was improvement of skin lesions, disappearance of eosinophilia and decrease of serum immunoglobulin E, towards normal values. Copyright (C) 2002 S.Karger AG, Basel.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5