In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases

• Type: Article in International Conference Proceedings Book
• Date: 2015

Authors

F. Guerra Liberal (Author) FEUP; Adriana Tavares (Author) FEUP; João Manuel R. S. Tavares (Author) FEUP

Conference proceedings National

Title: 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)

Pages: 1-6

2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG) Porto, Portugal 26-28 February 2015

Porto, Portugal, 26-28 February 2015

Indexing

ISI Web of Science

Scopus

INSPEC

Scientific classification

FOS: Engineering and technology

CORDIS: Technological sciences

Other information

DOI: 10.1109/ENBENG.2015.7088832

Abstract (EN): Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6