Red Wine Protects against Ethanol-Induced Oxidative Stress in Rat Liver

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Marco Assuncao (Author) Other; Maria J Santos Marques (Author) FMUP; Rosario Monteiro (Author) FMUP; Isabel Azevedo (Author) Other; Jose P Andrade (Author) FMUP; Felix Carvalho (Author) FFUP; Maria J Martins (Author) FMUP

Journal

Title: Journal of Agricultural and Food Chemistry

Vol. 57 No. 19

Pages: 6066-6073

ISSN: 0021-8561

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 21 Citations

ISI Web of Science

Scopus - 24 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

Other information

Authenticus ID: P-003-HF0

DOI: 10.1021/jf900576h

Abstract (EN): Ethanol consumption may be deleterious to the liver. However, alcoholic beverages contain, besides ethanol (EtOH), complex chemical mixtures that can modify EtOH's adverse effects. Red wine (RW) is rich in polyphenolic antioxidants, often reported as hepatoprotective agents. This study aimed to investigate the effects of 6 months of RW ingestion on hepatic oxidative stress and inflammation. Six-month-old Wistar rats were treated with RW or EtOH; controls were pair-fed. EtOH increased 8-hydroxy-2'-deoxyguanosine and decreased reduced and oxidized glutathione. These animals also displayed stimulated superoxide dismutase, catalase, and glutathione reductase activities. RW treatment decreased malondialdehyde and reduced glutathione levels. Glutathione-S-transferase and selenium-dependent glutathione peroxidase activities were stimulated and glutathione reductase activity was inhibited by RW intake. No modifications were detected in nuclear factor-kappa B or alkaline phosphatase activities. EtOH consumption induced fibrosis in portal spaces and hepatocyte lipid accumulation that were absent with RW treatment. This paper highlights the importance of RW nonalcoholic components and the relevance of biological matrix in the study of EtOH oxidative effects.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8