Temporal Trends in Peritonitis Rates, Microbiology and Outcomes: The Major Clinical Complication of Peritoneal Dialysis

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Ana Rocha (Author) Other; Anabela Rodrigues (Author) ICBAS; Laetitia Teixeira (Author) Other; Maria Joao Carvalho (Author) Other; Denisa Mendonca (Author) ICBAS; Antonio Cabrita (Author) Other

Journal

Title: Blood Purification

Vol. 33

Pages: 284-291

ISSN: 0253-5068

Publisher: Karger

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 27 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-G77

DOI: 10.1159/000337377

Abstract (EN): Peritonitis remains a common complication of peritoneal dialysis (PD). The aim of this study was to analyze, in a PD center, long-term temporal trends in peritonitis rates, microbiology and outcomes. We treated 588 cases of peritonitis that occurred during 11,833.6 months at risk. Y-set and twin-bag disconnecting systems were introduced in 1990, mupirocin at the exit site in 2000 and fluconazole prophylaxis in 2005. Vancomycin and ceftazidime were the empiric protocol. Global and 5-year cohort rates were expressed as episodes/patient-year (ep/p-y). A global peritonitis rate reduction was found from 1.02 to 0.47 ep/p-y (p = 0.008). Poisson analyses performed in each of the subgroups of Gram-positive and Gram-negative peritonitis revealed no significant changes over time. No case of vancomycin resistance was identified. There was a downward trend in peritonitis-related hospitalization over time to 0.11 ep/p-y (p <= 0.001). Trend analysis showed a favorable, but changing evolution, highlighting the importance of accurate longitudinal PD center registry data and quality control. Copyright (C) 2012 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8