| Summary: |
The increasing abuse of synthetic cannabinoids (SCBs), known as new psychoactive substances that bind and activate cannabinoid receptors, has become a major public health concern. SCBs are substantially more potent than tetrahydrocannabinol (THC) and, despite the scarce information regarding their toxicity, several cases of poisonings and deaths have been reported. Among consumers, pregnant or soon to be pregnant women comprise a particular risk group, due to the potential onset of neurodevelopment disorders in the offspring (e.g. schizophrenia, autism spectrum disorders, attention deficit and hyperactivity disorder). Assessment of SCBs modulation of neurodevelopmental processes, thus assumes critical relevance. These studies, which represent a significant step forward in understanding such SCB effects, may lead to the identification of potentially interesting therapeutic targets for neurodevelopment disorders and influence international policy-making decisions on drug prevention. |