The Acute Effects of a Fast-Food Meal Versus a Mediterranean Food Meal on the Autonomic Nervous System, Lung Function, and Airway Inflammation: A Randomized Crossover Trial

• Type: Article in International Scientific Journal
• Date: 2025

Authors

Silva, D. (Author) FMUP; Mendes, F.C. (Author) Other; Stanzani, V. (Author) Other; Moreira, R. (Author) Other; Pinto, M. (Author) Other; Beltrao, M. (Author) Other; Sokhatska, O. (Author) Other; Severo, M. (Author) Other; Padrão, Patrícia (Author) FCNAUP; Garcia-Larsen, V. (Author) Other; Delgado, L. (Author) FMUP; Moreira, André (Author) FMUP; Moreira, Pedro (Author) FCNAUP

Journal

Title: Nutrients

Vol. 17

Final page: 614

ISSN: 2072-6643

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-018-5WW

DOI: 10.3390/nu17040614

Abstract (EN): Background/Objectives: This study aimed to assess the acute effects of two isoenergetic but micronutrient-diverse meals-a Mediterranean-like meal (MdM) and a fast food-like meal (FFM)-on the autonomic nervous system (ANS), lung function, and airway inflammation response. Methods: Forty-six participants were enrolled in a randomized crossover clinical trial, consuming two isoenergetic meals: FFM (burger, fries, and sugar-sweetened drink) and MdM (vegetable soup, whole-wheat pasta, salad, olive oil, sardines, fruit, and water). Pupillometry assessed parasympathetic (MaxD, MinD, Con, ACV, MCV) and sympathetic (ADV, T75) nervous system outcomes. Lung function and airway inflammation were measured before and after each meal through spirometry and fractional exhaled nitric oxide (FeNO), respectively. Results: Mixed-effects model analysis showed that the MdM was associated with a hegemony of parasympathetic responses, with a significant increase of MaxD associated with a faster constriction velocity (ACV and MCV); on the other side, the FFM was associated with changes in the sympathetic response, showing a quicker redilation velocity (a decrease in T75). After adjusting for confounders, the mixed-effects models revealed that the FFM significantly decreased T75. Regarding lung function, a meal negatively impacted FVC (ae = -0.079, p < 0.001) and FEV1 (ae = -0.04, p = 0.017); however, FeNO increased, although after adjusting, no difference between meals was seen. Conclusions: Our study showed that the FFM counteracted the parasympathetic activity of a meal, while a meal, irrespective of the type, decreased lung function and increased airway inflammation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19